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. 2016 Sep 19;12(6):698–707. doi: 10.1007/s12015-016-9686-0

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — The detrended fluctuation analysis (DFA) α scaling exponents of the human induced pluripotent stem cell (hiPSC)-derived wild type- and long QT (LQT)-specific cardiomyocytes. The LQTs are grouped according to symptomatic (208.LQT1, 211.LQT1) and asymptomatic cases (303.LQT1, 313.LQT1) shown in the middle and in the right column, respectively. a) (row) β-blocker Bisoprolol, b) I_Ks activator ML277 c) I_Ks blocker JNJ303. At baseline, the α scaling exponents are close to 1 in all hiPSC-CMs. The addition of various compounds to the hiPSC-CMs increased the α scaling exponent closer to Brownian motion (α = 1.5). The asterisks on top of the bars depict the statistical significance for mean α scaling exponent change compared to baseline values. Significance levels are indicated by (*) p < 0.05, (**) p < 0.01 and (***) p < 0.001, respectively