Table 2.
Characteristics of patients with idiopathic pulmonary arterial hypertension (IPAH) and healthy subjects
| Parameter | Groups | P-value | |
|---|---|---|---|
| IPAH | Healthy subjects | ||
| n = 16 | n = 10 | ||
| Age [yr] | 58 ± 16 | 58 ± 15 | 0.97 |
| Gender female/male [n] | 12/4 | 6/4 | 0.42a |
| BMI [kg/m2] | 25 ± 6 | 24 ± 3 | 0.75 |
| 6MWD [m] | 490 ± 100 | 638 ± 110 | 0.002 |
| NT-proBNP [ng/l] | 667 ± 594 | 68 ± 27 | 0.004 |
| Cardiopulmonary exercise test (CPET) | |||
| Workload max [W] | 73 ± 32 | 130 ± 46 | 0.005 |
| Peak VO2/kg [ml/min/kg] | 15 ± 4 | 23 ± 5 | 0.001 |
| Peak VO2 [l/min] | 1.1 ± 0.4 | 1.7 ± 0.6 | 0.001 |
| EqCO2 at AT [l/min/l/min] | 47 ± 7.6 | 32 ± 2.2 | <0.001 |
| VO2 at AT [l/min] | 0.8 ± 0.2 | 1.2 ± 0.2 | 0.002 |
| HR rest/max [/min] | 78 ± 12/129 ± 28 | 77 ± 11/138 ± 18 | 0.90/0.35 |
| BP systolic rest/max [mm Hg] | 102 ± 20/149 ± 30 | 118 ± 22/179 ± 22 | 0.06/0.01 |
| BP diastolic rest/max [mm Hg] | 69 ± 12/80 ± 12 | 75 ± 10/81 ± 13 | 0.25/0.60 |
| Pulmonary function test (PFT) | |||
| FEV1 % predicted [%] | 78 ± 13 | 94 ± 8 | 0.002 |
| FVC % predicted [%] | 87 ± 13 | 95 ± 8 | 0.11 |
| FEV1/FVC [%] | 86 ± 11 | 102 ± 7 | <0.001 |
| DLCO % predicted [%] | 76 ± 15 | - | - |
Data are presented as mean ± SD or numbers. P-values are calculated by Students’ t-test and aChi-Square-test. 6MWD 6-min walk distance, AT Anaerobic threshold, BMI Body mass index, BP Blood pressure, EqCO2 Respiratory equivalent for carbon dioxide, FEV1 Forced expiratory volume in 1 s, FVC Forced vital capacity, HR Heart rate, IPAH Idiopathic pulmonary arterial hypertension, NT-proBNP N-terminal prohormone of brain natriuretic peptide, VO2/kg Maximum oxygen consumption per kilogram