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. 2016 Nov 11;16:880. doi: 10.1186/s12885-016-2883-z

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cumulative overall survival (OS) and recurrence-free survival (RFS) curves of patients with high and low expression of HMGB1 (panels a, b, e, and f) and high and low densities of CD68⁺ cell infiltration (panels c, d, g, and h) in tumoral and peritumoral liver tissues. In peritumoral liver tissues, the expression of HMGB1 and the density of CD68⁺ cells were both associated with poor OS and RFS (panels a, c, e, and g). In tumor tissues, the expression of HMGB1 was associated with poor OS but not RFS (panels b and f), while the density of CD68⁺ cells could not discriminate patients with different OS or RFS (panels d and h)