Fig. 2.

Levels of soluble PD-1 in the serum and bronchial alveolar lavage fluid of humans and mice with and without ARDS measured by ELISA. a sPD-1 levels in human serum in patients with ARDS (n = 10) compared to those without ARDS (n = 10). Analysis done by t test, *p = 0.036 when compared to patients without ARDS. b sPD-1 levels in mouse serum in mice with ARDS (n = 5) compared to those without ARDS (n = 6). Analysis done by t test, *p = 0.001 when compared to mice without ARDS. c sPD-1 levels in human bronchial alveolar lavage fluid in patients with ARDS (n = 13) compared to those without ARDS (n = 5). Analysis done by t test, *p = 0.002 when compared to patients without ARDS. d sPD-1 levels in mouse bronchial alveolar lavage fluid in mice with ARDS (n = 6) compared to those without ARDS (n = 7). Analysis done by t test, *p = 0.012 when compared to mice without ARDS. e PD-1ex3 expression in folds compared to GAPDH expression in patients with and without ARDS. Analysis done by rank sum test. *p = 0.002 when compared to patients without ARDS