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. 2016 Nov 11;13:79. doi: 10.1186/s12977-016-0310-9

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Secondary structural models of SL1. a Dissection of SL1 applied for this report. b Two models of SL1 predicted by Mfold program. The nucleotides at the bubble region substituted in the mutants are numbered. Five single substitution mutants and three double substitution mutants were constructed