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Inspection of G–C base pairing in the lower stem region of SL1. a The nucleotides substituted in the mutants. Six single substitution mutants (G to C or C to G) and three double substitution mutants (G–C to C–G or C–G to G–C) were constructed. b Growth kinetics of the mutants. c, d Packaging efficiency and dimerization ability of each mutant. The experiments were similarly performed as described in Figs. 1, 2
