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. 2016 Nov 11;16:146. doi: 10.1186/s12890-016-0309-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CHRNA5 gene expression levels in the lungs according to genotype groups for rs8040868. The left y-axis represents standardised gene expression levels in the lung with heterozygous genotype group set to zero. The x-axis represents the three genotyping groups, TT, CT and CC (risk allele C), for the variant in (a) the discovery set (Laval) n = 408; P = 4.2 × 10⁻¹⁰, and the replication sets (b) UBC, n = 287; P = 2.31 × 10⁻⁷, and (c) Groningen, n = 342; P = 1.5 × 10⁻⁶. The number of subjects per genotype group is indicated in parenthesis. The right y-axis shows the proportion of the gene expression variance explained by the variant (black bar)