Table 3.
Comparisons of Outcomes in the Four Latent Classes (LCs; n = 821 patients): The ELCAPA_09 Study
| Outcomes | Overall Population | LC1 | LC2 | LC3 | LC4 | p Values for Pairwise Comparisons* | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Relatively Healthy | Malnourished | Cognitive and/or mood impaired | Globally Impaired | LC1 Versus | LC2 Versus | LC3 Versus | |||||||
| N = 821 | N = 250 | N = 282 | N = 110 | N = 179 | Adjusted p Value† | LC2 | LC3 | LC4 | LC3 | LC4 | LC4 | ||
| One-year mortality | N (%) | 295/801 (36.8) | 24/247 (9.7) | 105/280 (37.5) | 37/102 (36.3) | 129/172 (75.0) | .021 | .030 | .120 | .001 | .980 | .555 | .624 |
| HR (95% CI) | 1.00 (Ref) | 2.33 (1.41–3.85) | 3.15 (1.75–5.66) | 5.47 (3.09–9.68) | <.001 | .002 | .002 | .002 | .180 | .002 | .020 | ||
| Unscheduled 6-month admission | N (%) | 291/743 (39.2) | 51/235 (21.7) | 117/259 (45.2) | 38/91 (41.8) | 85/158 (53.8) | . | . | |||||
| OR (95% CI) | 1.00 (Ref) | 1.87 (1.10–3.20) | 2.32 (1.15–4.67) | 2.33 (1.12–4.87) | .047 | .048 | .048 | .048 | .643 | .643 | .985 | ||
| Planned palliative treatment | N (%) | 380/732 (51.9) | 49/223 (22.0) | 131/256 (51.2) | 53/90 (58.9) | 147/163 (90.2) | |||||||
| OR (95% CI) | 1.00 (Ref) | 3.11 (1.63–5.91) | 5.21 (2.37–11.41) | 15.83 (4.16–40.68) | <.001 | .002 | .002 | .002 | .177 | .002 | .023 | ||
Notes: CI = confidence interval; HR = hazard ratio; OR = odds ratio. Qualitative data are number (%). Bold values are significant.
*Corrected probabilities using the false discovery rate correction for multiple comparisons.
†Global p values by logistic regression adjusted for in/outpatient status, age, year of inclusion, tumor site and metastatic status (planned palliative treatment), and planned treatment approach (6-month unscheduled admissions), and by Cox models stratified by in/outpatient status and adjusted for age, year of inclusion, planned treatment approach, and a composite variable based on tumor site and metastatic status (1-year mortality).