Table 3.

Associations of Modified HAI With CVD

Outcome	Events/N	HR (95% CI) Model 1	HR (95% CI) Model 2
Original HAI
HR per unit of index	103/857	1.27 (1.13, 1.42)	1.20 (1.01, 1.42)
HR per category of index
0–2	24/349	1.00	1.00
3–4	43/340	1.62 (0.97, 2.70)	1.41 (0.79, 2.53)
5–6	29/143	2.79 (1.58, 4.91)	1.98 (0.90, 4.36)
7–10	7/25	3.31 (1.38, 7.93)	2.47 (0.84, 7.25)
HAI including heart rate
HR per unit of index	103/839	1.25 (1.14, 1.38)	1.23 (1.07, 1.41)
HR per category of index
0–2	12/188	1.00	1.00
3–4	21/264	1.16 (0.57, 2.38)	1.10 (0.52, 2.32)
5–6	39/246	2.33 (1.20, 4.51)	1.98 (0.93, 4.24)
7–12	31/141	3.24 (1.62, 6.49)	2.31 (0.90, 5.93)
HAI including CRP
HR per unit of index	103/839	1.26 (1.14, 1.39)	1.23 (1.08, 1.41)
HR per category of index
0–2	6/197	1.00	1.00
3–4	36/294	3.72 (1.56, 8.85)	3.54 (1.46, 8.62)
5–6	33/227	4.03 (1.66, 9.76)	3.49 (1.35, 9.07)
7–12	28/121	7.78 (3.14, 19.26)	6.32 (2.20, 18.19)
HAI including heart rate and CRP
HR per unit of index	103/839	1.24 (1.14, 1.35)	1.23 (1.10, 1.39)
HR per category of index
0–2	4/112	1.00	1.00
3–4	13/196	1.85 (0.60, 5.69)	1.81 (0.58, 5.61)
5–6	33/244	3.80 (1.34, 10.79)	3.52 (1.20, 10.32)
7–10	48/272	4.94 (1.75, 13.94)	3.82 (1.22, 11.95)
11–14	5/15	9.42 (2.44, 36.38)	10.04 (2.18, 46.36)

Notes. HAI = Healthy Aging Index; CVD = cardiovascular disease; HR = hazard ratio; CI = confidence interval. Model 1 is adjusted for age, sex, physical activity index, smoking status, and body mass index. Model 2 is adjusted for the covariates in Model 1 and baseline cancer, hypertension, diabetes, kidney disease, and pulmonary disease.