Figure 2.

Phenotypic aberrations in Mdm2^PND/PND mice. (a) Comparative weights of age-matched wild-type and Mdm2^PND/PND mice at 6 weeks (left) and 1 year of age (right). Filled and unfilled circles represent males and females, respectively.±s.e.m., **P < 0.01. ns, non significant. (b) Hyperpigmentation in Mdm2^PND/PND mice. Yellow arrowheads point to the extremities with noticeable differences from wild-type mice. Panel on the right shows close up of tail and paws from wild-type and Mdm2^PND/PND mice. (c) Epidermal–dermal separation of wild-type and Mdm2^PND/PND mouse skin. (d) Hematoxylin and eosin (H&E)-stained longitudinal section of mouse tail showing melanin accumulation (black arrows) and spindled melanocytes (yellow arrow) in Mdm2^PND/PND mice (upper panel). Fontanna Masson (FM) stained tail sections from wild-type and Mdm2^PND/PND mice marking melanin (lower panel).