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Hematopoietic defects in Mdm2PND/PND mice. (a) Comparative red blood cell (RBC), white blood cell (WBC) and platelet counts from wild-type and Mdm2PND/PND mice. ±s.e.m., ****P < 0.0001. (b) Kaplan–Meier survival curve of wild-type and Mdm2PND/PND mice after 3 Gy IR.