Figure 5.

Distinct targets manifest p53-dependent pathologies. (a) Comparative weights of hearts and testes from Mdm2^PND/PND, Mdm2^PND/PND p53^+/−, Mdm2^PND/PND p21^−/− and Mdm2^PND/PND Puma^−/− mice. (b) Representative periodic acid–Schiff (PAS)-hematoxylin-stained testes (20×) and ovary (5×) cross-sections from Mdm2^PND/PND p53^+/−, Mdm2^PND/PND p21^−/− and hematoxylin and eosin (H&E)-stained section from Mdm2^PND/PND Puma^−/− mice. (c) Graphical representation of percentage of seminiferous tubule sections containing germ cells of different types in Mdm2^PND/PND p53^+/−, Mdm2^PND/PND p21^−/− and Mdm2^PND/PND Puma^−/− mice testes. (d) Representative picture showing changes in skin pigmentation in Mdm2^PND/PND paws after deletion of p53 or after combined deletion of p21 and Puma. *Seminiferous tubules without germ cells; AF, antral follicle; ATF, atreal follicle; CL, corpus luteum; GF, Graffian follicle; PAF, preantral follicle; PF, primary follicle; SF, secondary follicle.