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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Pharmacol Res. 2016 Sep 20;113(Pt A):438–448. doi: 10.1016/j.phrs.2016.09.020

Figure 4. Treatment with α-naphthyl tropolone induces apoptosis in Molt-4 cells.

Figure 4

(A-D) Cell apoptosis assay of vorinostat and tropolone derivatives in Molt-4 cells. Cells were treated with various concentrations of compounds for 24 hours, stained with Annexin V/FITC and propidium iodide and tested by Flow Cytometry. (A) α-naphthyl tropolone, (B) α-benzodioxinyl tropolone, (C) vorinostat, (D) Percentage of early apoptotic cells (Annexin V positive-PI negative) and late apoptotic cells (double positive). (E-F) Western blot of cleaved caspase 3 and cleaved caspase 7.