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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Pharmacol Res. 2016 Sep 20;113(Pt A):438–448. doi: 10.1016/j.phrs.2016.09.020

Figure 5. Caspase inhibitors block the tropolone-induced anti-proliferative effect.

Figure 5

Cells were pre-incubated with 100 μM Z-VAD-FMK for 1 hour and treated with α-naphthyl tropolone for (A) 24 hours or (B) 48 hours or α-benzodioxinyl tropolone for (C) 24 hours or (D) 48 hours. The same experiments were also performed in HuT78 Cells (E-H) and HL60 cells (I-L). Cell viability was assessed by Cell Quanti-Blue assay. Statistics were determined by ANOVA with Tukey’s post-hoc analysis and with p < 0.05. *indicates significant difference compared to condition with concentration 0. #indicates significant difference compared to each other.