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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Pharmacol Res. 2016 Sep 20;113(Pt A):438–448. doi: 10.1016/j.phrs.2016.09.020

Figure 6. Treatment with α-naphthyl tropolone enhances acetylation of histone H3 in Molt-4 cells which is blocked by pre-treatment with caspase inhibitor.

Figure 6

(A) Western blot of acetylated H3K23, H3K9 and H4K12 from Molt-4 cells treated with α-naphthyl tropolone (NAP, 10 µM) and α-benzodioxinyl tropolone (BEN, 10 µM) for 24 hours. (B) Quantification of histone acetylation levels after treatment in Molt-4 cells. (C) Cells were pre-incubated with 100 μM Z-VAD-FMK for 1 hour and treated with α-naphthyl tropolone for 24 hours. (D) Quantification of histone acetylation levels after tropolone treatment in the presence of Z-VAD-FMK in Molt-4 cells. *P < 0.05 by ANOVA with Tukey’s post-hoc analysis, compared to DMSO(C) (n=3).