Fig. 4.

NQO1-null mice have reduced A1AT levels and increased NE activity. (A) Effect of NQO1 deletion on A1AT protein expression in livers of male (left) and female (right) animals. (B–C) Serum samples were collected from WT and NQO1 KO animals. Serum A1AT levels were measured by ELISA, and serum NE activity was detected by a colorimetric assay. In all cases, statistical differences were determined in diet-paired groups of mice of the same sex using a student’s t-test. Data are represented as the mean ± SEM.