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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Curr HIV/AIDS Rep. 2016 Dec;13(6):318–327. doi: 10.1007/s11904-016-0342-8

Table 1.

Effect of HAART on neurocognitive deficits in HIV infected children.

Author Setting HAART regimens duration Spectrum and measures of Neurocognitive deficit after HAART Associations
Jeremy R, Pediatrics 2005 489 HIV +VE (4–17 yrs) US Protease inhibitor based 48 weeks No change in neurocognitive scores except vocabulary Viral suppression not linked with improvement in NP scores
Puthanakit, AIDS Care 2010 121 (39 HIV +VE, 40 exposed, 40 unexposed. Thailand NNRTI based median 35 weeks No change in Verbal scales of WISC after ART HIV infected had lower verbal scale of WISC than controls.
Shanbagh. Arch Pediatr. Adolesc. Med 2005 146 HIV +VE US Compared pre–HAART 1996 and post-HAART Progressive encephalopathy dropped from 27% to 12%
Wolters, Martin Dev. Neuropsychology 30(2) 41 HIV +VE (6–11 years) US National Cancer Institute. Protease-inhibitor based. At least 1 year WISC-III. Overall function in the average range Minimal to Moderate CT scan abnormalities and low CD4 count correlated with lower neurocognitive scores.