Table 3.
Effect of AOAA, NSC67078, hexachlorophene, aurintricarboxylic acid, tannic acid and benserazide (10, 30 and 100 μM) on CBS- and GYY4137 induced H2S/AzMC fluorescence responses and CBS-induced methylene blue H2S responses. Data are shown as mean ± SEM of n = 3 separate determinations.
| Compound | % inhibition of CBS −induced AzMC fluorescence | % inhibition of CBS −induced methylene blue signal | % inhibition of GYY4137 −induced AzMC fluorescence |
|---|---|---|---|
| AOAA (10 μM) | 80 ± 1 | 49 ± 3 | 3 ± 2 |
| AOAA (30 μM) | 89 ± 1 | 67 ± 1 | 2 ± 1 |
| AOAA (100 μM) | 94 ± 1 | 76 ± 1 | 1 ± 1 |
| NSC67078 (1 μM) | 47 ± 1 | 59 ± 2 | 25 ± 1 |
| NSC67078 (10 μM) | 88 ± 1 | 73 ± 1 | 65 ± 1 |
| NSC67078 (30 μM) | 93 ± 1 | 95 ± 1 | 78 ± 1 |
| Hexachlorophene (10 μM) | 3 ± 1 | 21 ± 1 | −4 ± 2 |
| Hexachlorophene (30 μM) | 12 ± 1 | 31 ± 1 | 1 ± 3 |
| Hexachlorophene (100 μM) | 70 ± 1 | 64 ± 1 | −2 ± 1 |
| Aurintricarboxylic acid (10 μM) | 72 ± 1 | 38 ± 2 | −3 ± 2 |
| Aurintricarboxylic acid (30 μM) | 87 ± 1 | 61 ± 1 | −2 ± 1 |
| Aurintricarboxylic acid (100 μM) | 94 ± 1 | 72 ± 1 | 6 ± 1 |
| Tannic acid (10 μM) | 28 ± 2 | 24 ± 9 | −1 ± 1 |
| Tannic acid (30 μM) | 43 ± 1 | 46 ± 3 | 3 ± 2 |
| Tannic acid (100 μM) | 75 ± 1 | 56 ± 3 | 8 ± 3 |
| Benserazide (10 μM) | 29 ± 1 | 24 ± 5 | 2 ± 2 |
| Benserazide (30 μM) | 44 ± 1 | 33 ± 3 | 4 ± 2 |
| Benserazide (100 μM) | 66 ± 1 | 50 ± 2 | 1 ± 1 |