Table 1.
Detailed demographics, clinical, and medication information of the study population.
| Bipolar Subjects (n=47) | Bipolar-Manic Subjects (n=23) | Bipolar-Euthymic Subjects (n=24) | Healthy Control Subjects (n=23) | Statistic | ||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Demographics | Bipolar vs Control | Control vs Mania | Mania vs Euthymia | Euthymia vs Control | ||||
| Age in years, mean (SD) | 29.3 (11.5) | 27.7 (11.1) | 30.9 (11.9) | 29.7 (10.9) | MW p=.527 |
MW p=.186 |
MW p=.076 |
MW p=.840 |
| Sex | df=1 χ2=.003 p=.956 |
df=1 χ2=.107 p=.743 |
df=1 χ2=.295 p=.587 |
df=1 χ2=.045 p=.831 |
||||
| male | 33 | 17 | 16 | 16 | ||||
| female | 14 | 6 | 8 | 7 | ||||
| Clinical Characteristics | ||||||||
| YMRS, mean (SD) | 14.4 (13.3) | 26.9 (5.70) | 2.33 (3.40) | n/a | MW p<.001 |
|||
| MADRS, mean (SD) | 8.89 (7.02) | 12.6 (6.60) | 5.33 (5.46) | n/a | MW p<.001 |
|||
| PANSS, mean (SD) | 49.3 (14.3) | 60.4 (10.3) | 38.6 (8.11) | n/a | MW p<.001 |
|||
| PANSS positive subscale, mean (SD) | 15.9 (8.11) | 22.7 (4.85) | 9.33 (4.24) | n/a | MW p<.001 |
|||
| Anticonvulsants | 17/47 | 8/23 | 9/24 | n/a | df=1 χ2= .038 p=.846 |
|||
| Antipsychotics | 37/47 | 22/23 | 15/24 | n/a | df=1 χ2=7.07 p=.006 |
|||
| CPZ equivalents, mean (SD) | 254 (253) | 370 (254) | 143 (200) | n/a | MW p=0.001 |
|||
| Benzodiazepines | 10/47 | 6/23 | 4/24 | n/a | df=1 χ2=.622 p=.430 |
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| Lithium | 34/47 | 18/23 | 16/24 | n/a | df=1 χ2= .789 p=.374 |
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| Antidepressants | 1/47 | 0/23 | 1/24 | n/a | df=1 χ2=.979 p=.322 |
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| framewise displacement in mm, mean (SD) | .136 (.058) | .140 (.066) | .133 (.051) | .121 (.071) | t(119) = 1.265 p=.208 |
t(73) = 1.218 p=.227 |
t(62)= .536 p=.594 |
t(84) = .918 p=.361 |
Abbreviations: MW: Mann-Whitney U Test, PANSS: Positive And Negative Symptom Scale, SD: Standard Deviation, YMRS: Young Mania Rating Scale.