Skip to main content
. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Pharmacol Res. 2016 Aug 19;113(Pt A):92–99. doi: 10.1016/j.phrs.2016.08.024

Fig. 1.

Fig. 1

Schematic illustrating the enzyme-stimulated multistage vector (ESMSV). a) A matrix metalloproteinase-2 (MMP2) peptide substrate was conjugated to poly(lactic-co-glycolic acid) (PLGA)- polyethylene glycol (PEG) nanoparticles, which were further conjugated to the surface of porous silicon microparticles. A hydrophobic model drug, coumarin 6, was encapsulated in the polymeric nanoparticles. b) In the presence of MMP2 enzymes, the polymeric nanoparticles disassociate from the silicon microparticles.