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Cellular uptake of polymeric nanoparticles (loaded with coumarin 6) released from MSVs or ESMSVs in A375 human melanoma cells. The cell culture medium was supplemented with MMP2. a) Quantitative measurements of cellurar uptake. Experiments were performed in triplicate and results are presented as mean ± SD. **, P < 0.001. b) Confocal microscopy images of cellular uptake. Nuclei were stained with DAPI. Scale bar, 20 μm.
