. Author manuscript; available in PMC: 2017 Dec 1.

Published in final edited form as: Acta Neuropathol. 2016 Oct 4;132(6):827–840. doi: 10.1007/s00401-016-1623-4

Table 2.

Serial passages in P0 G85R-SOD1:YFP mice injected intraspinally with the indicated inoculum

	# diseased / # injected	Average incubation period (months)	SD₅₀ of spinal homogenate^a
1^st Passage
G85R-YFP^G93A-P1	16/21	5.1 ± 0.8	10^1.7/µl
G85R-YFP^recWT-P1	5/6	10.1 ± 1.3	n.d.^b
G85R-YFP^G37R-P1	3/9	10.2 ± 2.0	10^1.6/µl
G85R-YFP^L126Z-P1	3/4	12.2 ± 3.3	n.d.
2^nd Passage
G85R-YFP^G93A-P2	8/8	2.8 ± 0.2	10^2.0/µl
G85R-YFP^recWT-P2	14/14	3.9 ± 0.1	n.d.
G85R-YFP^G37R-P2	5/6	5.4 ± 0.2	10^2.4/µl
G85R-YFP^L126Z-P2	4/5	5.9 ± 0.6	n.d.

SD₅₀ (seeding dose) determined in organotypic slice culture assay prepared from G85R-SOD1:YFP mice (n=5 slices per dilution)

Not done