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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Mol Cancer Res. 2016 Sep 13;14(11):1124–1135. doi: 10.1158/1541-7786.MCR-16-0083

Figure 7. DZNep and miRNAs suppress pancreatic cancer growth and metastasis in vivo.

Figure 7

A & B. DZNep and miRNAs reduced primary tumor burden in an orthotopic pancreatic xenograft model. Representative photographs of tumor xenografts (A) and excised tumor specimens (B) after 10 weeks of cell injections. C & D. Average tumor weights (C) and volumes (D) in DZNep treated and miRNA-expressed conditions. Each point represents data obtained from one mouse within a group. E. Representative images of tumor metastases to the liver with arrows pointing to metastatic foci. Tumor characteristics were confirmed by histopathology. F & G. DZNep, miR-663a, and miR-4787-5p reduced overall metastasis in secondary organs. F. The total number of metastatic nodules per mouse was added and plotted as a data point. The bar indicates mean number of lesions per mouse within a group. G. Metastatic incidences per organ. H. Average body weights of mice with each point representing average mice weight (n=6) for a group. I. DZNep induced regression of tumors in mice (n=3 for each group). Arrows indicate days of DZNep treatment. Bars, SD.