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. 2016 Jun 10;55(12):1495–1505. doi: 10.1007/s40262-016-0409-0

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Mean ± standard error of the mean treprostinil concentration vs. time plots by treatment regimen (semi-log). Tyvaso^® has been omitted from this figure as its systemic effects are not comparable with parenteral Remodulin^® or oral treprostinil (Data on file). Mean dose ± standard deviation of Remodulin^® (n = 32): 58.2 ± 19.2 ng/kg/min; total daily mean dose ± standard deviation of oral treprostinil twice daily (n = 6): 27 ± 12.3 mg; total daily mean dose ± standard deviation of oral treprostinil three times daily (n = 26): 37.9 ± 13.8 mg. bid twice daily, tid three times daily.

Data from a study sponsored by United Therapeutics Corp. The PK report from this study was dated Feb 2015