Table 3.

Comparison of total daily dose and pharmacokinetics in pulmonary arterial hypertension patients for various formulations and routes of administration of treprostinil

Product	IV or SC treprostinil	Inhaled treprostinil	Oral treprostinil
Dose	10 ng/kg/min	54 µg qid	2 mg bid	6 mg bid	7.5 mg tid
AUC24 (ng·h/mL)	40.7a	4.1 [18]b	32.0 [19]b	71.0 [19]b	113.2c
C max or C ss (ng/mL)	1.7a	1.0 [18]	3.0 [19]	5.3 [19]	11.2c

AUC area under the plasma concentration–time curve, AUC ₂₄ AUC from time zero to 24 h, bid twice daily, C _max maximum concentration, C _ss steady-stage concentration, IV intravenous, qid four times daily, SC subcutaneous, tid three times daily

^aEstimated from the formula derived by McSwain et al. [16]

^bEstimate of total daily AUC

^cEstimated from data obtained from White et al. [37]