Table 2.
Creatinine clearance (mL/min) | Probability of target attainment (%) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
30 % fT > MIC for MIC (mg/L) of: | 40 % fT > MIC for MIC (mg/L) of: | 50 % fT > MIC for MIC (mg/L) of: | ||||||||||
0.5 | 1 | 2 | 4 | 0.5 | 1 | 2 | 4 | 0.5 | 1 | 2 | 4 | |
80 | 99 | 99 | 99 | 98 | 99 | 99 | 99 | 94 | 99 | 98 | 97 | 89 |
100 | 99 | 99 | 99 | 97 | 99 | 99 | 98 | 92 | 99 | 98 | 95 | 85 |
120 | 99 | 99 | 99 | 96 | 99 | 99 | 97 | 89 | 99 | 98 | 94 | 80 |
MIC minimum inhibitory concentration, fT > MIC time free (unbound) drug concentration is above MIC