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. 2016 Jun 7;55(12):1507–1520. doi: 10.1007/s40262-016-0418-z

Table 2.

Probabilities of target attainment with ceftobiprole 500 mg administered as a 2-h infusion every 8 h [59]

Creatinine clearance (mL/min) Probability of target attainment (%)
30 % fT > MIC for MIC (mg/L) of: 40 % fT > MIC for MIC (mg/L) of: 50 % fT > MIC for MIC (mg/L) of:
0.5 1 2 4 0.5 1 2 4 0.5 1 2 4
80 99 99 99 98 99 99 99 94 99 98 97 89
100 99 99 99 97 99 99 98 92 99 98 95 85
120 99 99 99 96 99 99 97 89 99 98 94 80

MIC minimum inhibitory concentration, fT > MIC time free (unbound) drug concentration is above MIC