Table 5.

Pharmacodynamic analysis of ceftobiprole treatment in patients treated in the intensive care unit [71]

	Ceftobiprole 1000 mg (observed)			Ceftobiprole 500 mg (extrapolated)
	CLCR 50–79 mL/min	CLCR 80–150 mL/min	CLCR >150 mL/min	CLCR 80–150 mL/min	CRCR >150 mL/min
T > MICa (h)	19.6 ± 4.1	14.5 ± 6.0	12.0 ± 5.0	–	–
fT > MICa (h)	18.2 ± 4.0	13.2 ± 5.5	10.8 ± 5.2	9.5 ± 4.3	7.3 ± 3.9
%fT > MICa (q8 h)	>100	>100	>100	>100	91

Data are expressed as mean ± standard deviation, unless otherwise stated

CL _CR creatinine clearance, MIC minimum inhibitory concentration, T > MIC time the plasma drug concentration is above the MIC, fT > MIC time the free (unbound) drug concentration is above the MIC, q8 h every 8 h

^aMIC = 4 mg/L