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. 2016 Jun 28;55(12):1573–1589. doi: 10.1007/s40262-016-0422-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Changes in kidney function in females (left) and males (right) over the course of aging. To describe the influence of aging on the glomerular filtration rate (GFR), a new reverse sigmoid hyperbolic maturation function was developed and applied to both sexes, starting at the age of 30 years. Changes in the GFR were investigated by analysis of exogenous markers in prospective renal transplant donors. A stepwise regression analysis of the gathered data, normalized to body surface area (BSA), was performed for 1213 females (upper panel) and 1081 males (lower panel). A solid black line represents the new GFR function in relation to kidney weight, and a dashed black line represents the maturation of GFR function according to Rhodin et al. [127]. The grey shaded areas represent the predicted 95 % percentile range based on kidney size variability. The black circles depict the observed GFR rates [123–126]