Table 2.
Anthropometric measures, organ weights and tissue weights, including blood content, as used in the elderly physiologically based pharmacokinetic (PBPK) models
| Parameter | Sex | Age, years | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 30c | 40 | 50 | 60 | 70 | 80 | 90 | 100 | ||
| Body weight, kg | Female | 60.0 | 63.3 | 65.2 | 65.5 | 62.2 | 56.1 | 53.7 | 45.2 |
| Male | 73.0 | 74.4 | 73.0 | 72.0 | 71.1 | 68.1 | 64.9 | 55.6 | |
| Height, cm | Female | 163.0 | 160.9 | 160.0 | 158.3 | 155.4 | 151.7 | 150.0 | 147.9 |
| Male | 176.0 | 175.1 | 173.9 | 171.2 | 167.4 | 165.5 | 163.8 | 157.6 | |
| Organ masses, ga | |||||||||
| Blood poolsb | Female | 1899.4 | 1921.1 | 1961.2 | 1946.9 | 1847.7 | 1692.6 | 1634.5 | 1357.0 |
| Male | 2264.6 | 2269.5 | 2234.9 | 2180.2 | 2111.3 | 2042.5 | 1976.5 | 1739.5 | |
| Bone | Female | 9121.5 | 8886.3 | 8676.1 | 8401.8 | 7811.6 | 6981.4 | 6619.0 | 6263.5 |
| Male | 11,817.8 | 11,848.0 | 11,481.6 | 11,091.6 | 10,355.0 | 9637.1 | 8969.0 | 8300.9 | |
| Brain | Female | 1357.0 | 1352.3 | 1347.6 | 1315.1 | 1287.3 | 1241.4 | 1169.4 | 1097.4 |
| Male | 1508.8 | 1506.9 | 1502.9 | 1463.3 | 1434.3 | 1400.1 | 1372.1 | 1344.2 | |
| Fat | Female | 19,348.0 | 20,002.5 | 23,815.4 | 26,993.0 | 27,884.7 | 25,694.5 | 25,020.6 | 20,171.4 |
| Male | 14,868.0 | 16,309.7 | 16,676.5 | 17,920.7 | 19,447.4 | 19,947.7 | 20,691.0 | 17,082.3 | |
| Gonads | Female | 13.1 | 13.0 | 6.6 | 5.3 | 5.2 | 5.1 | 5.1 | 4.9 |
| Male | 40.3 | 40.8 | 35.0 | 33.5 | 31.9 | 30.6 | 30.3 | 29.5 | |
| Heart | Female | 328.4 | 340.0 | 355.6 | 377.1 | 399.1 | 413.5 | 431.2 | 412.9 |
| Male | 417.2 | 434.3 | 439.1 | 454.6 | 464.8 | 441.4 | 437.9 | 425.1 | |
| Kidney | Female | 403.4 | 401.7 | 400.5 | 383.4 | 364.2 | 325.2 | 308.8 | 295.8 |
| Male | 437.7 | 475.9 | 468.1 | 455.6 | 441.7 | 395.7 | 366.7 | 355.9 | |
| Liver | Female | 1905.5 | 1881.0 | 1867.7 | 1679.8 | 1504.9 | 1423.4 | 1329.5 | 1189.4 |
| Male | 2357.8 | 2324.5 | 2206.0 | 2041.3 | 1714.6 | 1417.3 | 1324.0 | 1202.0 | |
| Lung | Female | 1009.5 | 1021.4 | 1038.8 | 1023.8 | 1005.4 | 849.1 | 804.5 | 637.3 |
| Male | 1294.3 | 1334.7 | 1337.4 | 1349.0 | 1271.8 | 1138.0 | 1007.4 | 978.0 | |
| Muscle | Female | 20,276.2 | 23,058.3 | 21,300.1 | 18,971.2 | 15,746.4 | 13,367.8 | 12,394.3 | 10,060.6 |
| Male | 32,338.6 | 32,318.2 | 31,180.6 | 29,600.0 | 28,562.1 | 26,524.8 | 23,657.0 | 19,534.0 | |
| Pancreas | Female | 169.5 | 170.3 | 163.8 | 158.7 | 148.5 | 131.9 | 128.0 | 122.6 |
| Male | 190.3 | 190.8 | 183.6 | 178.2 | 165.4 | 149.9 | 143.7 | 139.5 | |
| Skin | Female | 2723.5 | 2773.2 | 2836.2 | 2829.5 | 2725.8 | 2559.1 | 2493.8 | 2223.5 |
| Male | 3760.9 | 3790.2 | 3745.1 | 3692.0 | 3635.2 | 3537.0 | 3439.7 | 3122.6 | |
| Spleen | Female | 219.2 | 197.7 | 190.7 | 182.4 | 164.5 | 149.7 | 99.4 | 78.7 |
| Male | 243.4 | 221.9 | 208.2 | 197.0 | 186.6 | 160.4 | 133.4 | 108.4 | |
aOrgan masses for gastrointestinal organs were kept constant for females (1274.5 g) and males (1304.8 g) over the investigated age range
bBlood pools represent arterial and venous blood, as well as blood in the portal vein
cPhysiological and anatomical information on the 30-year-old individuals is derived from the International Commission on Radiological Protection reference man [25]