Table 5.
Predictive performance analysis of the furosemide and morphine physiologically based pharmacokinetic (PBPK) models with and without age-informed physiology
| Furosemide | Morphine | |||||
|---|---|---|---|---|---|---|
| Adult physiology | Age-informed physiology | Adult physiology | Age-informed physiology | |||
| Adult data | Elderly data | Elderly data | Adult data | Elderly data | Elderly data | |
| Bias | ||||||
| ME | 0.032 (−0.034 to 0.010) | −0.339 (−0.621 to −0.057) | 0.076 (−0.015 to 0.137) | 0.082 (0.001 to 0.163) | −0.093 (−0.231 to 0.045) | 0.050 (−0.072 to 0.172) |
| Precision | ||||||
| RMSE | 0.180 (0.141 to 0.212) | 0.408 (0.004 to 0.721) | 0.276 (0.185 to 0.343) | 0.286 (0.189 to 0.358) | 0.437 (0.001 to 0.656) | 0.224 (0.004 to 0.384) |
| ΔRMSE | 0.132 (0.005 to 0.695) | 0.212 (0.001 to 0.635) | ||||
| Relative ΔRMSE | 32 % | 49 % | ||||
Values are expressed in mg/L with 95 % confidence intervals (in parentheses)
ME mean prediction error, RMSE root mean squared prediction error, ΔRMSE difference in RMSE