The course of healthy aging can be accounted for in a physiologically based pharmacokinetic (PBPK) model. The age dependence of distribution and elimination processes is described by literature-informed re-parameterization of organ volumes and blood flow rates.

A knowledge-driven whole-body PBPK model is a valuable tool for assessment of drug exposure in the elderly, facilitating optimization of dosing regimens and clinical trials with regard to the safety and efficacy profile of a given compound.