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Surface plot illustrating model results for the worst case scenario (Worst Case) analyzed in this study, which combines the Baseline Case and the 4 individual perturbations of 4 parameters (increase in islet diameter, increase in fractional viability, decrease in P ext, and addition of thrombus) that were shown separately in Figure 3. Note the very large anoxic volume fraction (AVF). AVF, anoxic volume fraction; P, oxygen partial pressure.
