Table 3.
Significant predictors of headache severity on univariate analysis in tuberculous meningitis (TBM) patients.
| Characteristic | Headache n (%) | Significance | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Total | Mild | Moderate | Severe | Intolerable | χ2 | P-value | |||||
| CSF protein >250mg/dl | 37 | 1 | (2.7) | 2 | (5.4) | 20 | (54.05) | 14 | (37.84) | 39.93 | 0.000 |
| Cranial nerve involvement | 52 | 7 | (13.5) | 15 | (28.85) | 16 | (30.8) | 14 | (26.92) | 14.35 | 0.002 |
| Vision involvement | 30 | 3 | (10.0) | 4 | (13.3) | 16 | (53.3) | 7 | (23.33) | 9.43 | 0.024 |
| Seizure | 44 | 3 | (6.8) | 3 | (6.8) | 28 | (63.6) | 10 | (22.73) | 36.55 | 0.000 |
| Neck rigidity | 73 | 12 | (16.4) | 17 | (23.3) | 32 | (43.8) | 12 | (16.44) | 10.36 | 0.016 |
| BMRC stage III | 33 | 0 | (0) | 7 | (21.2) | 11 | (33.3) | 15 | (45.45) | 41.75 | 0.000 |
| Headache character - throbbing | 46 | 6 | (13.0) | 13 | (28.3) | 21 | (45.65) | 6 | (13.04) | 26.47 | 0.002 |
| Headache location - holocranial | 57 | 1 | (1.75) | 10 | (17.5) | 30 | (52.6) | 16 | (28.07) | 56.50 | 0.001 |
| Meningeal enhancement | 42 | 6 | (14.3) | 6 | (14.3) | 19 | (45.2) | 11 | (16.84) | 10.46 | 0.015 |
| Basal exudates | 38 | 3 | (7.9) | 1 | (2.6) | 22 | (57.9) | 12 | (31.58) | 33.67 | 0.000 |
| Hydrocephalus | 42 | 5 | (11.9) | 7 | (16.7) | 24 | (57.1) | 6 | (14.29) | 14.19 | 0.003 |
| MBI <12 | 56 | 6 | (10.7) | 8 | (14.3) | 27 | (48.2) | 15 | (26.79) | 26.55 | 0.000 |
| TBM diagnosis definite | 53 | 5 | (9.4) | 10 | (18.9) | 24 | (45.3) | 14 | (26.42) | 23.53 | 0.001 |
BMRC - British Medical Research Council, MBI - Modified Barthel index