Skip to main content
. Author manuscript; available in PMC: 2017 Oct 21.
Published in final edited form as: ACS Chem Biol. 2016 Aug 17;11(10):2752–2762. doi: 10.1021/acschembio.6b00404

Figure 6. Assessment of peptides 1 and 2 as antagonists of PTH(1–34) induced calcemic and phosphatemic responses in mice.

Figure 6

Data points represent mean SEM. *p<0.05 versus vehicle in n = 6 or 7 female CD1 mice. Experiments were run according to the schematic provided in supporting figure S5.(a–b) Peptide 1 or 2 or vehicle was injected four minutes prior to PTH(1–34). See methods section for further experimental details. (a) Levels of ionized calcium within the bloodstream of mice treated with 1, 2, or vehicle. (b) Levels of inorganic phosphate within the bloodstream of mice treated with 1, 2, or vehicle.(c–d) Peptide 1 or 2 or vehicle was injected one hour after PTH(1–34). Experiments were run according to the schematic provided in supporting figure S5. See methods section for further experimental details. Black arrows represent the time at which 1, 2, or vehicle were injected. (c) Levels of ionized calcium with in the bloodstream of mice treated with 1, 2, or vehicle. (d) Levels of inorganic phosphate within the bloodstream of mice treated with 1, 2, or vehicle.