Table 2. Results from univariate and multiple logistic regression.

Variable	Univariate Analyses				Multivariable Model 1 (N=1639)			Multivariable Model 2 (N=1661)
	N	OR	95% CI	P	OR	95% CI	p	OR	95% CI	p
Contralateral knee OA	1667	4.262	3.134, 5.824	<0.001	2.834	1.970, 4.085	<0.001	2.763	1.985, 3.855	<0.001
Baseline KL Grade 1 (Index)	1690	3.974	2.931, 5.417	<0.001	2.667	1.891, 3.777	<0.001	2.576	1.848, 3.603	<0.001
BMI	1690	1.092	1.064, 1.122	<0.001	1.066	1.034, 1.099	0.004	1.063	1.033, 1.093	<0.001
Average WOMAC Score	1684	1.034	1.025, 1.043	<0.001	1.024	1.012, 1.036	<0.001	1.023	1.013, 1.033	<0.001
Multiple Joint OA	1690	1.676	1.092, 2.504	0.014	1.322	0.807, 2.113	0.255
Prior Surgery (Contralateral)	1688	1.489	0.987, 2.184	0.049	0.859	0.521, 1.385	0.543
Knee Alignment Varus (Index)	1668	1.078	01.00, 1.158	0.045	1.051	0.968, 1.137	0.227
Frequent Pain (Contralateral)	1690	1.291	1.037, 1.603	0.019	0.917	0.641, 1.256	0.619
CES-D depression score	1663	1.019	1.000, 1.038	0.041	0.994	0.971, 1.017	0.633
Baseline KL Grade 1 (Contralateral)	1160	3.080	1.894, 4.976	<0.001
Prior Surgery (Index)	1689	0.853	0.410, 1.593	0.643
Prior Injury (Index)	1683	1.140	0.784, 1.627	0.480
Prior Injury (Contralateral)	1685	1.224	0.884, 1.678	0.215
Knee Alignment Valgus (Index)	1668	0.906	0.784, 1.031	0.157
Knee Alignment Valgus (Contralateral)	1655	0.997	0.900, 1.093	0.956
Knee Alignment Varus (Contralateral)	1655	1.135	1.007 1.201	<0.001
Frequent Pain (Index)	1690	1.175	0.900, 1.498	0.203
Gender (Female)	1690	0.847	0.623, 1.144	0.283
Age	1690	1.005	0.986, 1.024	0.579