Skip to main content
. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: Behav Brain Res. 2016 Oct 13;317:502–507. doi: 10.1016/j.bbr.2016.10.024

Figure 1. Hindpaw inflammation decreases wheel running in male and female rats.

Figure 1

CFA or saline was injected into the right hindpaw of male (Top) and female (Bottom) rats. Injection of saline caused a transient decrease in running that returned to baseline levels within 3 hrs. In contrast, injection of CFA caused a complete and prolonged inhibition of wheel running in both male and female rats. Sample sizes ranged from 49 – 68 rats in each condition. The sample sizes are large because these rats were subsequently tested with different opioid doses.