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. Author manuscript; available in PMC: 2018 Jan 15.
Published in final edited form as: Behav Brain Res. 2016 Oct 13;317:502–507. doi: 10.1016/j.bbr.2016.10.024

Figure 2. Low doses of morphine briefly restore inflammation-depressed wheel running.

Figure 2

Male and female rats injected with 0.32 or 1.0 mg/kg of morphine 24 hours after CFA administration showed an increase in wheel running during the hour following the injection. Only the 1.0 mg/kg dose of morphine reached statistical significance compared to the vehicle-treated controls, but analysis of individual rats showed that injection of 0.32 mg/kg of morphine restored running in 7 of 10 male rats and 4 of 9 female rats. Rats injected with the highest dose of morphine (3.2 mg/kg) did not differ from rats receiving saline – running was depressed in both groups. Sample sizes ranged from 6 – 10 rats/condition. * indicates p<.05 from saline-treated animals.