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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Pain Symptom Manage. 2016 Sep 21;52(5):695–708.e4. doi: 10.1016/j.jpainsymman.2016.04.014

Table 4.

Multiple Logistic Regression Analyses for Cytokine Genes and Lower Fatigue Versus Higher Fatigue Classes

Predictor Odds Ratio Standard Error 95% CI Z p-value
IL1B rs16944 2.98 1.215 1.336, 6.626 2.67 .008
Age 0.96 0.012 0.936, 0.984 −3.17 .002
KPS score 0.94 0.017 0.911, 0.978 −3.21 .001
SCQ score 1.10 0.062 0.998, 1.243 1.73 .083
Any chemotherapy 2.26 0.655 1.284, 3.992 2.83 .005
Overall model fit: χ2 = 56.98, p <.0001
IL10 rs3024496 0.34 0.120 0.172, 0.682 −3.05 .002
Age 0.95 0.013 0.930, 0.979 −3.58 <.001
KPS score 0.95 0.017 0.916, 0.980 −3.09 .002
SCQ score 1.12 0.063 1.007, 1.255 2.08 .037
Any chemotherapy 2.32 0.675 1.315, 4.106 2.90 .004
Overall model fit: χ2 = 60.96, p <.0001

Multiple logistic regression analyses of candidate gene associations with Lower Fatigue versus Higher Fatigue classes (n=301). For each model, the first three principal components identified from the analysis of ancestry informative markers, as well as self-reported race/ethnicity, were retained in all models to adjust for potential confounding due to race/ethnicity (data not shown). For the regression analyses, predictors evaluated in each model included genotype (IL1B rs16944: GG+GA versus AA; IL10 rs3024496: TT+TC versus CC, age (5 years increments), functional status (KPS score in 10 unit increments), self-administered comorbidity questionnaire score, and receipt of chemotherapy within six months after surgery.

Abbreviations: any chemotherapy = receipt of chemotherapy within six months after surgery, CI = confidence interval, IL1B = interleukin 1 beta, KPS = Karnofsky Performance Status, SCQ = Self-administered Comorbidity Questionnaire