Table 3. Factors associated with disease progression in patients with pulmonary nontuberculous mycobacterial (PNTM) disease.
| Parameter | Disease progression | ||||
|---|---|---|---|---|---|
| Univariate | Multivariate | ||||
| OR (95% CI) | P value | OR (95% CI) | P value | ||
| Female (vs. male) | 1.13 (0.48, 2.63) | 0.786 | |||
| Age >70 (vs. ≤70) years | 1.85(0.79, 4.35) | 0.159 | |||
| Disease extension of more than two-thirds | 1.68 (0.69, 4.09) | 0.252 | |||
| Past TB history | 2.17 (0.92, 5.11) | 0.078 | 1.72 (0.49, 6.03) | 0.396 | |
| Cavity | 3.24 (1.34, 7.84) | 0.009 | 2.83 (0.83, 9.69) | 0.097 | |
| BMI <19.5 mg/kg2 | 2.10 (0.89, 4.95) | 0.09 | 0.93 (0.28, 3.06) | 0.907 | |
| Decrease in cholesterol level >20 mg/dL | 11.06 (3.59, 34.10) | <0.001 | 10.50 (2.51, 43.98) | 0.001 | |
| Decrease in cholesterol level >30 mg/dL | 7.84 (2.03, 30.36) | 0.003 | |||
| Decrease in lymphocyte count >200/μL | 9.43 (3.36, 24.46) | <0.001 | 5.32 (1.46, 19.35) | 0.011 | |
| Decrease in lymphocyte count >300/μL | 9.92 (3.22, 30.56) | <0.001 | |||
| Decrease in visceral fat area >20 cm3 | 2.47 (0.79, 7.67) | 0.119 | |||
| Decrease in visceral fat area >30 cm3 | 1.06 (0.22, 5.04) | 0.943 | |||
| Anti-NTM treatment | 1.85 (0.79, 4.35) | 0.159 | |||
| Disease duration >3 year | 1.91 (0.79, 4.59) | 0.146 | |||
| M. abscessus | 2.72 (0.94, 7.88) | 0.065 | 1.36 (0.29, 6.33) | 0.692 | |
| AFB positivity | 1.20 (0.51, 2.78) | 0.68 | |||
TB, tuberculosis; BMI, body mass index; AFB, acid fast bacilli.