Table 5.
Clinical data pre- and post-anti-tumour necrosis factor therapy
| Non-responder (n = 12) | Responder (n = 12) | P value | |
| (n or mean ± SEM) | (n or mean ± SEM) | ||
| Pre-anti-TNF therapy | |||
| Immunosuppressant | |||
| Thiopurine | 7 | 6 | NS |
| Tacrolimus | 2 | 0 | NS |
| Prednisone | 9 | 7 | NS |
| Prednisone/thiopurine | 6 | 2 | NS |
| Methotrexate | 1 | 0 | |
| 5-ASA | 6 | 5 | NS |
| ESR | 42.5 ± 12.9 (n = 7) | 33.1 ± 10.4 (n = 7) | NS |
| CRP | 36.3 ± 10.1 (n = 11) | 27.4 ± 7.4 (n = 12) | NS |
| Partial Mayo1 | 7.3 ± 0.5 (n = 7) | 7.5 ± 0.2 (n = 11) | NS |
| Post-anti-TNF therapy | |||
| Immunosuppressant | |||
| Thiopurine | 12 | 8 | NS |
| Tacrolimus | 4 | 0 | 0.045 |
| Prednisone | 6 | 0 | 0.007 |
| Prednisone/thiopurine | 0 | 0 | |
| Methotrexate | 0 | 0 | |
| 5-ASA | 6 | 4 | NS |
| ESR | 22.9 ± 7.9 (n = 4) | 13.5 ± 4.7 (n = 9) | NS |
| CRP | 51.2 ± 14.6 (n = 12) | 4.6 ± 1.2 (n = 12) | 0.0043 |
| Partial Mayo1 | 7.6 ± 0.4 (n = 12) | 0.3 ± 0.2 (n = 12) | < 0.0001 |
1
Partial Mayo scores presented as not all patients had endoscopic examination at time of blood draw. CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate.