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. 2016 Nov 7;22(41):9127–9140. doi: 10.3748/wjg.v22.i41.9127

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Gastric lesions, sum of the longest lesions diameters, mean ± SD, mm, in rats that underwent esophagogastric anastomosis. Medication (/kg) given intraperitoneally (ip) (once time daily) or continuously in drinking water (po) after the creation of an esophagogastric anastomosis in rats. BPC 157 (10 μg, 10 ng), L-NAME (5 mg), and L-arginine (100 mg) given alone and/or combined intraperitoneally with the first application at 30 min after anastomosis creation and the last at 24 h before sacrifice. Drinking water alone (12 mL/d per rat) or BPC 157 in drinking water (10 μg, 10 ng/kg; 0.16 μg, 0.16 ng/mL) was provided continuously until sacrifice. ^aP < 0.05, at least, vs control.