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. 2016 Nov 7;22(41):9127–9140. doi: 10.3748/wjg.v22.i41.9127

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Illustrative microscopic presentation in rats that underwent esophagogastric anastomosis at post-operative day 4 [controls (c), BPC 157 (b)] and at post-operative day 7 [BPC 157 (B)], hematoxylin eosin staining. Tissue destruction at the anastomosis edges (arrows) were consistently noted in controls (c), which is a presentation that precedes lethal outcome. Initial organization of the exudate (b) (arrows) and wound completely closed with granulation tissue (B) (arrows), which is consistently noted in rats that underwent esophagogastric anastomosis and were treated with BPC 157.