Table 3. Changes in abdominal fat areas by computed tomography scan in the GCL2505-supplemented (N=69) and placebo (N=68) groups during the treatment period.
| Treatment period |
Time × group a | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 week |
8 weeks |
12 weeks |
|||||||
| Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | ||||
| VFA (cm2) | Actual values | GCL2505 | 133.4 | 126.4, 140.4 | 127.3 | 120.0, 134.6 | 128.3 | 121.2, 135.5 | 0.004 |
| Placebo | 124.3 | 118.0, 130.6 | 125.2 | 118.5, 132.0 | 125.8 | 119.3, 132.3 | |||
| Change from 0 week | GCL2505 | - | −6.8## | −10.6, −2.9 | −5.1# | −8.6, −1.5 | |||
| Placebo | - | 0.9 | −2.6, 4.4 | 1.5 | −1.3, 4.3 | ||||
| SFA (cm2) | Actual values | GCL2505 | 215.9 | 202.7, 229.0 | 213.7 | 200.9, 226.6 | 214.8 | 201.7, 227.8 | 0.676 |
| Placebo | 219.9 | 209.5, 230.2 | 216.0 | 204.9, 227.1 | 219.8 | 208.6, 231.0 | |||
| Change from 0 week | GCL2505 | - | −2.4 | −5.9, 1.2 | −1.1 | −5.2, 3.0 | |||
| Placebo | - | −3.9 | −7.6, −0.1 | −0.1 | −3.8, 3.6 | ||||
| TFA (cm2) | Actual values | GCL2505 | 349.3 | 335.0, 363.5 | 341.0 | 326.6, 355.5 | 343.1 | 328.8, 357.4 | 0.111 |
| Placebo | 344.2 | 333.3, 355.1 | 341.2 | 329.2, 353.3 | 345.6 | 333.4, 357.7 | |||
| Change from 0 week | GCL2505 | - | −9.1 | −14.2, −4.0 | −6.2 | −11.9, −0.5 | |||
| Placebo | - | −3.0 | −8.4, 2.5 | 1.4 | −3.6, 6.4 | ||||
Values are means and 95% confidence intervals (CIs). VFA: visceral fat area; SFA: subcutaneous fat area; TFA: total fat area.
There was a significant difference between the groups, as determined using an unpaired t-test with Bonferroni correction. #p<0.05; ##p<0.01.
ap-value represented as a group-by-time interaction effect by two-factor repeated-measures ANOVA using actual values.