Table 1.

Inclusion and Exclusion Criteria for the Partial Nephrectomy Arm of the Study

Inclusion criteria	Exclusion criteria
At least 18 years old	Known anaphylactic or allergic reactions to folate and its analogs
Proven or suspected diagnosis of cT1-2 RCC by CT assessment	Known sensitivity to fluorescent light
Scheduled for partial nephrectomy	Renal impairment (baseline GFR below 50 mL/min/1.73 m2)
Expected survival of at least 3 months	Hepatic disorders (CTCAE version 4 definition ≥ grade 2)
Good performance status (ECOG ≤1)	Brain metastases
Negative serum or urine pregnancy test within 24 hours before partial nephrectomy (for females of child-bearing age)	Participation in another investigational drug trial within 30 days before partial nephrectomy
Willingness to participate after the process of informed consent	Any medical conditions that, in the opinion of the investigators, could potentially jeopardize patient's safety, limit the patient's ability to complete the study, or compromise the objectives of the study

CTCAE = Common Terminology Criteria for Adverse Events; ECOG = Eastern Cooperative Oncology Group; GFR = glomerular filtration rate; RCC = renal-cell carcinoma.