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Mechanism of action of anti-tumor necrosis factor antibodies in inflammatory bowel disease. Schematic illustration of different modes of action of anti-TNF antibodies in inflammatory bowel diseases. TNF: Tumor necrosis factor; mTNF: Membrane-bound TNF; sTNF: Soluble TNF; TNFR: TNF receptor; NK cell: Natural killer cell; ADCC: Antibody-dependent cellular cytotoxicity; CD: Crohn’s disease; CDC: Complement-dependent cytotoxicity; LPS: Lipopolysaccharide.
