Table 2.
Predictive parameters of lymphovascular invasion between hematoxylin and eosin and D2-40 and Elastica van Gieson in small rectal neuroendocrine tumors n (%)
|
LVI (H&E only) |
LVI (D2-40 and EVG) |
||||||
| Total | Present | Absent | P vaule | Present | Absent | P vaule | |
| n = 104 | n = 26 (25.0%) | n = 78 (75.0%) | n = 29 (27.9%) | n = 75 (72.1%) | |||
| D2-40 and EVG | 0.648 | - | |||||
| LVI (+) | 29 (27.9) | 18 (69.2) | 11 (14.1) | - | - | ||
| LVI (-) | 75 (72.1) | 8 (30.8) | 67 (85.9) | - | - | ||
| Age (yr) | 48.20 ± 10.93 | 50.27 ± 11.28 | 47.51 ± 10.80 | 0.282 | 47.86 ± 11.16 | 48.33 ± 10.91 | 0.847 |
| Sex | 1.000 | 0.650 | |||||
| Male | 67 (64.4) | 17 (65.4) | 50 (64.1) | 20 (69.0) | 47 (62.7) | ||
| Female | 37 (35.6) | 9 (34.6) | 28 (35.9) | 9 (31.0) | 28 (37.3) | ||
| AV distance (cm)1 | 8.09 ± 3.25 | 8.35 ± 2.72 | 8.01 ± 3.41 | 0.687 | 7.59 ± 2.87 | 8.25 ± 3.37 | 0.412 |
| Tumor size | 0.038 | 0.007 | |||||
| ≤ 5 mm | 62 (59.6) | 11 (42.3) | 51 (65.4) | 11 (37.9) | 51 (68.0) | ||
| > 5 mm | 42 (40.4) | 15 (57.7) | 27 (34.6) | 18 (62.1) | 24 (32.0) | ||
| Tumor depth | 0.571 | 0.558 | |||||
| Mucosa | 3 (2.9) | 0 (0) | 3 (3.8) | 0 (0) | 3 (4.0) | ||
| Submucosa | 101 (97.1) | 26 (100) | 75 (96.2) | 29 (100) | 72 (96.0) | ||
| Tumor grade | 1.000 | 0.006 | |||||
| Grade 1 | 95 (91.3) | 24 (92.3) | 71 (91.0) | 20 (69.0) | 68 (90.7) | ||
| Grade 2 | 9 (8.7) | 2 (7.7) | 7 (9.0) | 9 (31.0) | 7 (9.3) | ||
| Ki 67% | 1.46 ± 1.01 | 1.08 ± 1.05 | 0.113 | 1.54 ± 1.13 | 1.03 ± 0.97 | 0.023 | |
| Ki 67 index | 0.627 | 0.213 | |||||
| < 3% | 98 (94.2) | 24 (92.3) | 74 (94.9) | 26 (89.7) | 72 (96.0) | ||
| ≥ 3% | 6 (5.8) | 2 (7.7) | 4 (5.1) | 3 (10.3) | 3 (4.0) | ||
| Mitotic count | 0.65 ± 0.84 | 0.39 ± 0.69 | 0.125 | 0.82 ± 0.88 | 0.32 ± 0.97 | 0.001 | |
| Mitosis/10HPF | 0.357 | 0.005 | |||||
| < 2 | 93 (89.4) | 22 (84.6) | 71 (91.0) | 22 (75.9) | 71 (94.7) | ||
| ≥ 2 | 11 (10.6) | 4 (15.4) | 7 (9.0) | 7 (24.1) | 4 (5.3) | ||
1
The tumor location is measured from anal verge. Bold values: P value < 0.05. HPF: High power field; LVI: Lymphovascular invasion; H&E: Hematoxylin and eosin stain.