Figure 11.

Ultrastructural changes in the hepatocytes of linagliptin-treated db/db mice. A: Heterogeneity of the hepatocytes: Cells with numerous lipid inclusions (1), cells with areas of hyperplasia of smooth ER and lipid vacuoles (2), cells with a relatively uniform distribution of organelles and rare lipid inclusions (3); B: Cells without hyperplasia of the smooth ER with a relatively homogenous distribution of organelles; distinct microvilli on vascular poles of the hepatocytes and on the lateral sides of parenchymal cells; the extension of spaces between hepatocytes (arrows); C and D: Plots of clusters of smooth ER membranes. L: Lipid inclusion; m: Mitochondria; s: Lumen of the sinusoid; SER: Smooth endoplasmic reticulum; bc: Bile capillary.