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. 2016 Nov 15;7(19):534–546. doi: 10.4239/wjd.v7.i19.534

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©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Ultrastructural changes in the hepatocytes of intact db/db mice. A: Fields of “foamy” hyperplastic smooth ER and fields of glycogen, lipid inclusions in the cytoplasm of hepatocytes; B and E: Pronounced exocytosis of vacuoles with lipid content into the Disse space (arrows); C and D: Pronounced exocytosis of vacuoles with lipid content into gaps between hepatocytes (arrows); F: The bile capillary (white arrow) and compartments of the mito-ER-complexes (complexes from ER and mitochondria), active Golgi complexes, residual bodies and autophagosomes (black arrow) at the biliary poles of hepatocytes. V: Microvilli on the lateral surface of hepatocytes; L: Lipid inclusions; m: Mitochondria; e: Erythrocyte; EPR: Endoplasmic reticulum.