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TLR2 and TLR4 signaling pathways and aging. This figure illustrates intracellular TLR signaling pathways as discussed in the text of this article. Red arrows and dashed boxes signify components of signal transduction pathways that are found to be involved in age-related monocyte/macrophage dysfunction (11–13, 16, 46). To see this illustration in color, the reader is referred to the web version of this article at www.liebertpub.com/ars
