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. 2016 Nov 14;7:453. doi: 10.3389/fimmu.2016.00453

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Copyright © 2016 Kazzaz, Sule and Knight.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanisms of platelet activation and heterotypic intercellular interactions that may regulate NETosis. Some are more speculative than others, as described in the text. Abbreviations: GPIb, glycoprotein 1b; GPIIb/IIIa, glycoprotein IIb/IIIa; HMGB1, high-mobility group box 1; LFA-1, lymphocyte function-associated antigen 1; LPS, lipopolysaccharide; Mac-1, macrophage-1 antigen; PAR, protease-activated receptor; PSGL-1, P-selectin glycoprotein ligand 1; RAGE, receptor for advanced glycation end products; TLR2, toll-like receptor 2; TLR4, toll-like receptor 4; TXA₂, thromboxane A₂; vWF, Von Willebrand factor.